In Knuckles comic #13, the Chaotix eat stuff, them kinda go crazy. I'm not quite sure how it effects Espio, though. Could you help me ?
The chili dogs they ate had the Lemon Sundrop Dandilion drug in them, which has different effects. Espio pretty much threw up, and Charmy was hit the worst as you see in the last page of the same issue. The Chaotix ended up getting emergency medical attention in issue 14 and they were fine, although Charmy was a bit worse for wear.

~ SA Tails